Micky van de Ven Brace Ends Everton's Run at New Stadium
The Dutch defender emerged as the initial backline player to net two goals in a English top-flight match for Spurs since the Belgian defender in March 2013.
Match summary
Micky Van de Ven nods home twice in opening period
Everton's defender has goal disallowed after video check
Pape Matar Sarr nets third in 89th minute
The defeat is Everton's first at their new ground
Micky van de Ven found the net on two occasions as Spurs extended their unbeaten run in away games in the Premier League and handed the Toffees their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their last five matches at their new ground at the dockside location, having left their historic home behind after more than a century at the conclusion of last season.
But Tottenham's leader Van de Ven struck twice from set-pieces in the first half to put their strong form at risk, and they were unable to turn it around before Pape Matar Sarr - set up by ex-Everton forward Richarlison - nodded in a final goal to put the game to bed.
Jake O'Brien believed he had equalized the scores a short while after Van de Ven's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, failed to convert a number of opportunities, while Vicario made a succession of fine saves to ensure Tottenham went five matches on the road without defeat in the English top flight.
But the video assistant referee stepped in, advising the match official to check the score on the screen and the referee ruled that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Spurs keeper.
The win elevates the manager's team up to third in the Premier League, a handful of points off local foes and leaders the Gunners.
The Merseyside club remain in 14th position and sit half a dozen points clear of the relegation zone.
Spurs breakdown: The defender fulfils duties at both ends of the field
After a drab midweek display in the Champions League against the French side, where they managed a only attempts on target, the manager chose Randal Kolo Muani up front instead of ex-Everton forward Richarlison.
The summer signing was failed to influence the game before being substituted for the substitute after an hour on the field, but it turns out he wasn't needed in the final outcome.
Defender Van de Ven converted into an offensive threat to be reckoned with.
Spurs' opening strike came from a cleverly executed corner routine, with Rodrigo Bentancur heading the ball back across the face of goal for an unmarked the defender to head home.
And the captain - stepping up as captain in the Argentine's absence - notched his second in first-half stoppage time as he outjumped Jordan Pickford to head home.
The Dutchman was just as outstanding in defence, partnering well with his defensive colleague as the pair dealt excellently with the numerous deliveries thrown their way by the opposition.
Everton analysis: Toffees missing finishing touch
The club's recent stadium had been a happy hunting ground, but it seems the novelty may have worn off slightly and supporters headed to the gates after Sarr's third for Spurs.
The break in Everton's unbeaten home run won't be a massive worry for the manager, but their striker situation are.
Beto and Thierno Barry - the Everton's pair of recognised centre-forwards - had netted only one league goal combined before the weekend's outing.
And they were unable to add to that miserable tally on a wet and gloomy night on Merseyside.
Beto's performance was summed up when he opted to bicycle-kick a golden opportunity from near the goal, despite having space and opportunity to reposition for a more conventional shot that would have tested Vicario.
Barry, too, was unable to influence the game after coming on for the starter in the 65th minute.
It wasn't for a lack of opportunity. Most of the home side's offensive moves came through Grealish and Ndiaye, who tirelessly delivered dangerous balls into the Tottenham box.
What next for these two sides?
Everton: Moyes' men head to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: The London club travel to St James' Park on Wednesday, 29 October for their next round Carabao Cup tie against the Magpies.